Western blot and qPCR confirmed the increased expression of p53 and p21 after IPA treatment.<h4>Conclusion</h4>IPA inhibits PCa cell proliferation, migration, and invasion, while inducing cell cycle arrest and apoptosis concurrent with the activation of the p53 signaling pathway, suggesting its potential as a new therapeutic option for PCa. Here, TP53 is linked to posterior cortical atrophy.