PALB2 and cancer: Models were adjusted for birth year, sex (when applicable), smoking status, and body mass index; stratified analyses assessed modification by family history of cancer.<h4>Results</h4><i>PALB2</i> P/LP variant prevalence was 1:571 in UK Biobank and 1:940 in MyCode, with the higher prevalence in the UK cohort driven by the <i>PALB2</i> p.Trp1038Ter founder variant.