XRCC3 and laryngotracheoesophageal cleft: Finally, preliminary validation using RT-qPCR in a limited cohort of clinical samples indicated that the expression trends of three prognostic genes were elevated in LC tissues, showing concordance with the bioinformatic findings.<h4>Conclusions</h4>This study identified four key prognostic T-RGs (CHTF18, FANCG, NR5A1, and XRCC3) and constructed a corresponding prognostic model for LC.