Menin scaffolds the oncogenic histone-lysine-N-methyltransferase (KMT2A)-fusion protein (FP) complex in <i>KMT2A-</i>r and wild-type <i>KMT2A</i> complex in <i>NPM1</i>-m acute myeloid leukemia (AML). This evidence concerns the gene NPM1 and acute myeloid leukemia.