Menin scaffolds the oncogenic histone-lysine-N-methyltransferase (KMT2A)-fusion protein (FP) complex in <i>KMT2A-</i>r and wild-type <i>KMT2A</i> complex in <i>NPM1</i>-m acute myeloid leukemia (AML). The gene discussed is MEN1; the disease is acute myeloid leukemia.