IL3 and Cognitive impairment: Behavioral testing, flow cytometry, immunofluorescence, and multiplex cytokine analyses were used to assess cognitive performance, glial activation and oxidative stress, astrocyte-microglia IL-3/IL-3R signaling, endothelial activation, selective immune cell accumulation at CNS borders, tissue organization, and hippocampal cytokine profiles.<h4>Results</h4>HLA mice developed age- and sex-dependent cognitive impairment, most pronounced in aged females.