Moreover, SAHA inhibited the expression of ERS pathway proteins, including PERK and CHOP, in NB cell lines.<h4>Conclusion</h4>This study demonstrated that SAHA downregulates HLA-E expression by inhibiting the PERK/ATF4/CHOP pathway, offering new insights into the regulation of tumor proliferation, migration, and immune evasion in NB. The gene discussed is ATF4; the disease is neuroblastoma.