Statistical analyses were conducted in R and Python.<h4>Results</h4>scRNA-seq identified five CRC tumor cell subtypes, among which the C4 <i>BCL2L1<sup>+</sup></i> tumor cells (TCs)subtype was predominantly enriched in liver metastases and displayed enhanced proliferation, metabolic reprogramming, and anti-apoptotic activity. The gene discussed is BCL2L1; the disease is colorectal carcinoma.