We focused on enrichment related to neurodegeneration/cognition and inflammatory pathways, and compared the expression of AD-related genes (PSEN1, PSEN2, BACE1, and MME) between ILD and NDC.<h4>Results</h4>ILD patients showed significantly lower MMSE total scores than healthy controls, with notable declines in attention/calculation and orientation. The gene discussed is PSEN2; the disease is Alzheimer disease.