This study investigated whether the transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) attenuates hypertensive myocardial fibrosis and remodelling by modulating the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)] axis. Here, CEBPB is linked to Myocardial fibrosis.