We show that tumour cell plasticity, defined by podoplanin (PDPN)-expression and promoted by hypoxia, intersects with CCR7 function in triple-negative breast cancer (TNBC).<h4>Methods</h4>In vivo and in vitro studies using a CCR7-expressing TNBC mouse model were combined with transcriptomic profiling. The gene discussed is PDPN; the disease is triple-negative breast carcinoma.