<h4>Purpose</h4>To comprehensively characterize the clinical and genomic landscapes of <i>PIK3CA</i>, <i>AKT1</i>, and <i>PTEN</i> alterations and examine their functional and therapeutic implications in AKT-driven breast cancer.<h4>Methods</h4>Comprehensive genomic profiling of 51,767 breast tumors was performed using FoundationOne CDx or FoundationOne. The gene discussed is PTEN; the disease is breast neoplasm.