The combined AUC for differential diagnosis of PIMA was the highest for Kurtosis, Entropy, plasma FoxM1, and Sox9 mRNA levels.<h4>Conclusion</h4>CT radiomic parameters and the plasma mRNA levels of FoxM1 and Sox9 among patients with PIMA were closely associated with tumor differentiation and TNM staging, offering invaluable references for the differential diagnosis of PIMA. The gene discussed is SOX9; the disease is neoplasm.