This study aimed to investigate the regulatory effect of RFWD2 on the downstream protein, serum/glucocorticoid-regulated kinase 1 (SGK1), through the JNK pathway and explore its influence on AD pathogenesis.<h4>Methods</h4>Cognitive-level behavioral detection was performed in RFWD2<sup>+/-</sup> mice. This evidence concerns the gene MAPK8 and Alzheimer disease.