The optimal cutoff value of ANGPTL8 for identifying high AIP was 227.18 ng/mL (sensitivity = 68.40%; specificity = 68.00%; <i>P</i> < 0.001; AUC = 0.780; 95% CI: 0.714-0.847).<h4>Conclusions</h4>The serum ANGPTL8 levels are elevated in T2D patients with high AIP. This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.