<h4>Purpose</h4>The purpose of this study is to investigate the value of a radiomics model based on diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for preoperative prediction of telomerase reverse transcriptase (TERT) promoter mutation status in gliomas.<h4>Methods</h4>This retrospective study included 126 patients with pathologically confirmed gliomas who underwent TERT promoter mutation testing between January 2020 and June 2025. The gene discussed is TERT; the disease is central nervous system cancer.