ROC analysis showed that MIF (AUC = 0.873) and CXCR4 (AUC = 0.929) exhibited strong diagnostic performance while TNFAIP3 (AUC = 0.142) and miR-181a-5p (AUC = 0.201) demonstrated weak accuracy consistent with their opposite expression patterns between CML patients and healthy controls.<h4>Conclusion</h4>The findings of this study suggested that increased miR-181a expression may be associated with reduced TNFAIP3 levels and modified NF-κB related inflammatory signaling in CML. This evidence concerns the gene CXCR4 and chronic myelogenous leukemia, BCR-ABL1 positive.