LAPTM4A and acute kidney injury: <h4>Introduction</h4>Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), but specific therapeutic targets are lacking.Lysosomal Protein Transmembrane 4A (LAPTM4A), a four transmembrane-spanning protein mainly localized in endosomes and lysosomes,however, its pathological role in AKI remains unexplored.<h4>Methods</h4>To investigate the impact of LAPTM4A on renal IRI, we developed an in vivo renal IRI model utilizing LAPTM4A knockout mice, alongside an in vitro hypoxia-reperfusion(H/R) model employing shRNA to knockdown LAPTM4A in HK2 cell.