ITGAM and Sepsis: Transcriptomic profiling corroborated these promoter states, linking accessibility with gene expression.<h4>Conclusions</h4>These findings define promoter-level epigenetic classes across a targeted locus panel in splenic CD11b<sup>+</sup>Gr1<sup>+</sup> cells within this murine sepsis model and generate mechanistic hypotheses regarding age- and sex-associated chromatin states.