To identify anti-glioma myeloid cell effectors, we performed directionally concatenated ligand-receptor (L-R) interactome analyses from dendritic cells (DCs) and microglia (MG) to lymphoid (CD4<sup>+</sup>T, Tregs, CD8<sup>+</sup>T, NK, and NKT) cells identified by our recent single-cell transcriptomics interrogation of tumor-associated CD45<sup>+</sup> leukocytes from tumor brains of eighteen isocitrate dehydrogenase (IDH)-stratified glioma patients. Here, CD4 is linked to central nervous system cancer.