Finally, the findings were validated and compared using data from the National Health and Nutrition Examination Survey (NHANES).<h4>Results</h4>Higher PRAL (odds ratio [OR]: 1.004, 95% confidence interval [CI]: 1.002-1.006) and NEAP (OR: 1.009, 95% CI: 1.005-1.012) were associated with an increased prevalence of diabetes and prediabetes. The gene discussed is PRAL; the disease is prediabetes syndrome.