StringTie identified previously unannotated isoforms at LINC02692 (+2.23), LINC01605 (-0.62), ZNF793 (-2.33), ZNF382 (-1.87), and retained-intron transcripts at RAD51 (+1.30), RPS24 (-0.97), and RPS3A (-0.62).<h4>Conclusions</h4>Poorly differentiated endometrial carcinomas in Black South African women show a distinct MAPK-linked activation pattern, along with transcriptional repression and extensive splicing changes. Here, RAD51 is linked to endometrial carcinoma.