LAMC2 and neoplasm: <i>In vitro</i> assays assessed the acidic microenvironment's impact on LAMC2 expression, with functional evaluations of LAMC2 overexpression and knockdown on cellular behaviors.<h4>Results</h4>The LAMC2 mRNA levels were elevated across multiple tumor types and correlated with unfavorable prognoses in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).