<i>In vitro</i> assays assessed the acidic microenvironment's impact on LAMC2 expression, with functional evaluations of LAMC2 overexpression and knockdown on cellular behaviors.<h4>Results</h4>The LAMC2 mRNA levels were elevated across multiple tumor types and correlated with unfavorable prognoses in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). This evidence concerns the gene LAMC2 and squamous cell lung carcinoma.