Disease-relevant models can help resolve these questions.<b>Hypothesis.</b> We hypothesized that bacterial inoculation could drive CRS-associated symptoms in a murine model.<b>Aim.</b> To characterize host-microbe interactions in a murine model of sinonasal bacterial infection.<b>Methodology.</b> <i>Staphylococcus aureus</i> and/or <i>Pseudomonas aeruginosa</i> were inoculated in the nasal cavity of Swiss Webster, C57Bl/6, Balb/c and B6.Cg-<i>Prkdc</i> <sup>scid</sup>/SzJ severe combined immunodeficient (SCID) mice. Here, PRKDC is linked to congenital rubella syndrome.