This illustrates that the EZH2/NLRP6 axis plays a critical regulatory role in EC pyroptosis and suggests its potential as a therapeutic target in pulpitis.<h4>Conclusions</h4>In summary, this study establishes ECs as key regulators in pulpitis inflammation, highlighting EZH2's role in modulating NLRP6 and the potential mechanism of pyroptosis in ECs. Here, NLRP6 is linked to pulpitis.