In contrast, the occurrence of hypertension was significantly associated with the daily average dose (25.53 vs. 1.81 IU/day, p = 0.021), the initial dose (22.12 vs. 9.29IU, p < 0.001) and initial average dose (2.73 vs. 1.21 IU/kg, p < 0.001) of ACTH.<h4>Conclusion</h4>Both the duration and cumulative dose of ACTH therapy are positively correlated with the incidence of AEs. This evidence concerns the gene POMC and hypertensive disorder.