Furthermore, Thymic hyperplasia is associated with T-cell-related autoimmune diseases, and increased expression of WNT4 and FOXN1 are beneficial to the growth of thymic cells and the maintenance of the thymic microenvironment.<h4>Methods</h4>The samples were obtained from surgical patients who met the criteria, and this study was ethically approved. Here, WNT4 is linked to autoimmune disease.