Evidence was synthesized qualitatively, with emphasis on mechanistic plausibility, tissue specificity, translational readiness, and safety considerations relevant to T2DM and its complications.<h4>Results</h4>Preclinical studies consistently demonstrate that clearance of senescent cells in adipose tissue, liver, and pancreatic islets improves insulin sensitivity, attenuates SASP-mediated inflammation, and preserves β-cell function across multiple diabetic models. The gene discussed is INS; the disease is type 2 diabetes mellitus.