<h4>Background</h4>We evaluated the diagnostic performance of anthropometry-adjusted triglyceride-glucose (TyG)-derived indices for assessing insulin resistance (IR) in Japanese adults without diabetes, using the euglycemic-hyperinsulinemic clamp (EHC) as the reference standard.<h4>Methods</h4>A total of 61 Japanese individuals without diabetes underwent insulin sensitivity assessment using the gold standard EHC. Here, INS is linked to diabetes mellitus.