Notably, the cytokines Pentraxin-3 and IL-8 showed positive correlations with calcium, copper, iron, antimony, and chromium, suggesting a possible functional relationship in neuroinflammation.<h4>Discussion</h4>In conclusion, this study presents a comparative analysis of CSF metal and metalloid levels in conjunction with inflammatory cytokine profiles in a pediatric population, providing a basis for further research into their roles in neuroinflammation and neurological disease. This evidence concerns the gene PTX3 and nervous system disorder.