Western blot and qPCR further confirmed the upregulation of these genes in HBV-related fibrotic liver tissues at both protein and mRNA levels.<h4>Conclusions</h4>In summary, CCND1 and IL7R are core JAK-STAT pathway genes associated with HBV-related liver fibrosis, with IL7R showing a significant causal role. Here, IL7R is linked to Hepatic fibrosis.