Comparing patients and healthy controls' nasal mucosal sample, glycan metabolism was significantly upregulated, while retinol metabolism was downregulated.<h4>Conclusion</h4>The main pathways in the polyps are associated with tissue remodeling, increased renin-angiotensin-aldosterone system activation, ferroptosis, decreased antimicrobial defense as local microenvironmental risk factors contributing to the recurrence of CRSwNP. This evidence concerns the gene REN and chronic rhinosinusitis with nasal polyps.