Functional studies were performed to assess lung injury, immune responses, CD8<sup>+</sup> T cell abundance, and survival following <i>Blautia</i> or metabolite administration.<h4>Results</h4>Gut microbiome analysis identified significant <i>Blautia</i> depletion in SI-ALI patients compared to healthy controls. This evidence concerns the gene CD8A and acute respiratory distress syndrome.