HERV-W ratio correlated positively with Z-sNfL (ρ=0.67, p=0.012), Z-sGFAP (ρ=0.54, p=0.048), MSSS, and proinflammatory cytokines (IL-6, IL-1β and CXCL-9/10) specifically in AMS and SMS-EDSS>4 subgroups. The gene discussed is IL1B; the disease is ablepharon macrostomia syndrome.