E2F2 and congestive heart failure: RT-qPCR confirmed that YQHXCP significantly reversed the downregulation of Cdk1 and E2f2 expression in the myocardial tissue of CHF rats.<h4>Conclusion</h4>YQHXCP may exert its anti-CHF effects by targeting Cdk1 and E2f2 to regulate mitochondrial function and cell cycle homeostasis.