Additionally, genes associated with epithelial-mesenchymal transition (EMT) were upregulated, and <i>VEGF-C</i> and <i>AR</i> expression increased at pH 6.8 (<i>p</i> < 0.05).<h4>Conclusion</h4>The efficacy of bicalutamide in prostate cancer cells is significantly influenced by extracellular pH. This evidence concerns the gene VEGFC and Familial prostate cancer.