PTGS2 and rheumatoid arthritis: Molecular docking further supported the structural plausibility of direct interactions between representative active compounds-such as quercetin and berberine-and core RA-related targets, including TNF-α and PTGS2.<h4>Discussion</h4>This integrative analysis demonstrates that heterogeneous TCM prescriptions used in RA converge on shared inflammatory regulatory networks while retaining prescription-specific mechanistic features.