Furthermore, experimental results from the <i>in vitro</i> cell model confirmed that the expression patterns of the core genes were consistent with findings from the bioinformatics analysis.<h4>Conclusion</h4>This research preliminarily suggests that CXCL10, EDNRB, and MMP13 may serve as potential oxidative stress-related biomarkers for RA. Here, EDNRB is linked to rheumatoid arthritis.