Immunohistochemical staining revealed a trend toward an increased number of gelsolin-positive cells in the chorionic membrane of chorioamnionitis cases.<h4>Conclusion</h4>Plasma gelsolin decreases with the progression of pregnancy and intrauterine inflammation and may particularly reflect the progression of intrauterine inflammation in cases of preterm premature rupture of membrane. This evidence concerns the gene GSN and chorioamnionitis.