Viral/nonviral chimeric nanoparticles (ChNPs) composed of a BIM-expressing adeno-associated virus (AAV) core and a degradable polymeric shell that encapsulates MCL-1 siRNA (BIM/MCL-1 ChNPs) selectively killed BCR-ABL + CML cells in combination with dasatinib. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.