DMD and Duchenne muscular dystrophy: <h4>Background</h4>The restoration of uniformly distributed dystrophin protein expression is an important consideration for the development of advanced therapeutics for Duchenne muscular dystrophy (DMD).<h4>Methods</h4>We have generated a novel genetic mouse model (mdx52-Xist<sup>Δhs</sup>) that expresses variable and nonuniformly distributed dystrophin protein from birth as a consequence of skewed X-chromosome inactivation.