White matter exhibited significantly higher binding than grey matter ( P  < 0.01), but no disease-specific differences were noted.<h4>Conclusion</h4>This study demonstrates P2X7 receptor-specific binding of [ 18 F]JNJ-64413739 but finds no significant differences between post-mortem tissue of Alzheimer's disease cases and controls. Here, P2RX7 is linked to Alzheimer disease.