DUSP26 and Alzheimer disease: However, the impact of LC lesions during prodromal stages is poorly characterized.<h4>Methods</h4>TgF344-AD and wild-type rats received monthly injections of DSP-4 or saline from 1-5 months of age, a time point preceding forebrain plaque or tangle deposition in TgF344-AD rats, after which behavior and pathology were assessed.<h4>Results</h4>DSP-4 compromised LC cell bodies, fibers, and NE content.