ARHGEF2 and Sepsis: GEF-H1 represents a promising therapeutic target, and its inhibition by agents such as Epothilone A may offer a novel strategy for treating sepsis.<h4>Key points</h4>Gzma induces the dephosphorylation of Ser886 on GEF-H1, activating the RhoA/ROCK pathway and disrupting the intestinal epithelial barrier.