CIT and colorectal cancer: In the largest cohort (N = 1090), multivariable HR for high vs. low CD66b<sup>+</sup> granulocyte density was 0.53 (95%CI 0.38-0.73, P<sub>Trend</sub> < 0.001).<h4>Conclusion</h4>Our findings indicate that while neutrophil infiltration is associated with favorable colorectal cancer outcomes, the presence of intratumoral Cit-H3<sup>+</sup> NETs does not predict survival.