PHP reduced body weight and serum Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), insulin, total cholesterol, creatinine, C-peptide, and total oxidant status, while increasing serum SIRT6, total antioxidant status, Homeostatic Model Assessment of β-cell function (HOMA-β), nesfatin-1, glucagon-like peptide-1 (GLP-1), and insulin-like growth factor-1 (IGF-1); however, these changes were not statistically significant (p > 0.05). Here, NUCB2 is linked to Insulin resistance.