Ultimately, we constructed a TFs-mRNA-miRNAs network comprising 39 nodes (16 TFs, 22 miRNAs, and 1 mRNA) and 38 edges.<h4>Conclusion</h4>PTEN was preliminarily identified and verified as a key ferroptosis gene in postmenopausal osteoporosis through bioinformatics analysis, and the diagnostic model constructed based on PTEN was of high value. This evidence concerns the gene PTEN and postmenopausal osteoporosis.