According to the receiver operating characteristic curve analysis, the predictive value of the combination of the three indicators [the FGF23 level, National Institutes of Health Stroke Scale (NIHSS) score and modified Rankin scale (mRS) score] for the occurrence of MACCEs in AIS patients was greater than that of any of them alone (<i>p</i> < 0.05), while the difference between the three indicators was not statistically significant. Here, FGF23 is linked to stroke disorder.