GPX4 and Autoimmunity: Increased <i>Fasl</i> and decreased <i>Gpx4</i> expression suggested glandular apoptosis and ferroptosis concomitant with ELS formation.<h4>Conclusion</h4>ELS form spontaneously in the LG of the male NOR mouse model of SjD and can recapitulate features of secondary lymphoid organs potentially acting as drivers of autoimmunity to sustain local glandular disease.