Additionally, experimental validation using qPCR and ELISA assays was conducted <i>in vitro</i>, <i>in vivo</i>, and in patient plasma to confirm the expression patterns of key genes.<h4>Results</h4>Across integrated public bulk, single-cell, spatial, and blood multi-omics, CXCL13, IL33, TLR4, and IGF1 were identified as core IPF genes consistently linked to immune infiltration and fibrotic remodeling. This evidence concerns the gene TLR4 and idiopathic pulmonary fibrosis.