Given that ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and NLRP3 activation, this study aims to investigate the therapeutic effects and underlying mechanisms of POG in a murine model of UC induced by dextran sulfate sodium (DSS), and to evaluate its potential translational significance for UC intervention.<h4>Methods</h4>A DSS-induced UC mouse model was employed to evaluate POG's therapeutic efficacy. The gene discussed is NLRP3; the disease is ulcerative colitis.